Endocrine Abstracts

Introduction: Multiple endocrine neoplasia, type 2A (MEN 2A) is a hereditary syndrome characterized by medullary carcinoma of the thyroid, pheochromocytoma, parathyroid hyperplasia or adenomas due to mutation in RET oncogene on chromosome 10. Complications can occur as a result of ectopic ACTH causing Cushings syndrome. We present here a case initially presenting to hospital with worsening shortness of breath on a background of metastatic medullary thyroid can...

Arginine vasopressin resistance (AVP-R) (previously termed nephrogenic diabetes insipidus) is well known to be associated with lithium treatment. However, cases are usually mild and patients can almost always compensate for their polyuria with excessive fluid intake. We present the case of a moribund patient who required intensive care admission secondary to AVP-R, developing hypernatraemia to 183mmol/l and serum osmolality of 394mmol/kg. A 68 year old gentleman, on lithium tr...